Polyphenol gentiopicroside is extraction of component a regeneration effect on human skin active components from various plant gentiopicroside in. It is an activation of the proteasome system effectively, can be re activated cell regeneration plant. If the skin with polyphenol gentiopicroside processing, when the younger then, initial symptoms reached by the activation of proteasome function can delay aging. Through this effective degradation of damaged proteins (detoxification), cell division ability to rebuild, and to keep the dynamic balance of long; its resistance to ultraviolet light caused by aging or oxidative stress was improved.

Plant bitter glycoside extract treated keratinocytes to proteasome proteolytic activity doubled. Alone with corresponding keratinocyte polyphenol bitter glycosides treatment even more activation of proteasome strong. The active ingredient in an impressive way of promoting the proteasome activity; make better degradation of damaged proteins.

In vitro study further, the active ingredient of this display to enhance the skin cells resistant to stress, slow down the aging speed of skin cells.

Verify the eye area skin regeneration

PRIMOS method was used to compare with the different age of the untreated control group as compared to the active ingredient and then smear before the eye region (crow's feet) depth of wrinkles. The parameter RMax measurement (maximum roughness).

A total of *0 participants aged between ****0 years old skin types were involved in this study. The subjects were divided into 4 age groups. Before the start of the study they all measuring depth of wrinkles, it can calculate the regression line. 2 groups of older subjects in a *8 day trial two times a day with 3% active ingredients in the crow's feet area light gel. Fill again measured depth of wrinkles on the fourteenth day and the twenty-eighth.

Results: (Fig. **2)

After a) applied for *4 days and *8 days, in *5% and *3% of participants were observed significant effect. Overall, applied for *4 days and *8 days later, wrinkle depth showed a statistically significant decline, of about 9% and *5% respectively. One of the biggest . One of the biggest decline in value to *0%. From the photos can be seen, apparently Ping Fu effects of the components on the wrinkles can be observed with the naked eye can.

B) with *4 and *8 days later, at the age of ****5 years old group of participants (mean age *4.4 years) wrinkle depth display to calculate way can respectively reach *1.1 and *8.3 year old subjects value. It is in the *4 and *8 days makes the wrinkling degree aged 3.3 and 6.1 years of age.

Apply the *4 and *8 days later, the age that in ****0 years old (average age *7.2) by wrinkle depth test personnel display to calculate way respectively reached *4.3 and *1.9 year old subjects value. This is makes the wrinkling degree young 2.9 years old and 5.3 years old.